Week In Science

'Genome-wide natural antisense transcription: coupling its regulation to its different regulatory mechanisms,' EMBO reports 7, 12, 1216–1222 (2006)doi:10.1038/sj.embor.7400857, addresses a matter that probably merits more attention- NATs or natural antisense transcripts. The nature of DNA double strands allows for generation of nucleotides from a template. It also provides a natural regulatory construct. While one strand can code for a protein, the other has potential to regulate the sense transcript. Regulatory mechanisms can be many and varied. The model referenced by the report could identify particular regulatory mechanisms by the expression patterns of NATs and their targets.