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Dealing with DSBs During the Cell Cycle
Submitted by Paul on Thu, 2007-11-22 05:22.
A Nature paper titled Human CtIP promotes DNA end resection by Alessandro A. Sartori, Claudia Lukas, Julia Coates, Martin Mistrik, Shuang Fu, Jiri Bartek, Richard Baer, Jiri Lukas and Stephen P. Jackson (Nature 450, 509-514 (22 November 2007); doi:10.1038/
nature06337) reports a finding that the human protein CtIP (RBBP8), recruited to double-strand breaks (DSBs) exclusively during the S and G2 cell-cycle phases, is needed for DSB resection. Also documented is CtIP's interaction with the MRE11 complex; both of which are needed for efficient homologous recombination.